Article
Single and multiple mutations in the human cytomegalovirus UL97 gene and their relationship to the enzymatic activity of UL97 kinase for ganciclovir phosphorylation.
Antiviral research - 1 Nov 2009
Sanchez Puch Silvia I, Mathet Verónica L, Porta Margarita, Cuestas María L, Oubiña José R, Videla Cristina M, Salomón Horacio E
Abstract excerpt
In this study we determined that the double mutant M460V/D605E in the UL97 gene of an HCMV isolate from an immunocompromised patient (MMT isolate) is related to resistance to ganciclovir (GCV) therapy. Our results suggest that the aspartic acid-to-glutamic acid substitution at codon 605 may be associated with a natural polymorphism of the UL97 gene, and not with positive selection pressure exerted by the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.