Article
A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir.
Antimicrobial agents and chemotherapy - 1 Jan 2000
Chou S, Meichsner C L
Abstract excerpt
A deletion mutation (codons 595 to 603) in the cytomegalovirus (CMV) UL97 gene was recently reported after sequence analysis of leukocyte DNA from a patient receiving ganciclovir. The corresponding viral phenotype was examined by transfer of this mutation to a laboratory CMV strain (strain Towne). The recombinant virus was resistant to ganciclovir (8.4-fold increase in the 50% inhibitory concentration), was...
Topics
- Antiviral Agents
- Codon
- Cytomegalovirus
- Drug Resistance, Microbial
- Ganciclovir
- Gene Deletion
- Genes, Viral
- Humans
- Mutation
- Phosphotransferases