Article
Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance.
The Journal of infectious diseases - 1 Mar 1995
Chou S, Erice A, Jordan M C, Vercellotti G M, Michels K R, Talarico C L, Stanat S C, Biron K K
Abstract excerpt
The UL97 phosphotransferase coding sequences of clinical cytomegalovirus (CMV) isolates, 10 resistant and 11 sensitive to ganciclovir, were compared to define mutations associated with drug resistance. In each ganciclovir-resistant isolate, a mutation was found that resulted in an amino acid subs...
Topics
- Amino Acid Sequence
- Base Sequence
- Codon
- Cytomegalovirus
- Drug Resistance
- Ganciclovir
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Phosphotransferases