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Article

Cytomegalovirus UL97 mutations affecting cyclopropavir and ganciclovir susceptibility.

Antimicrobial agents and chemotherapy - 1 Jan 2011

Chou Sunwen, Bowlin Terry L

Abstract excerpt

Among the 7 most common UL97 mutations encountered in ganciclovir-resistant clinical cytomegalovirus isolates, the associated cyclopropavir cross-resistance varies from insignificant (L595S) to substantial (M460I and H520Q) as determined by recombinant phenotyping. Mutations M460I and H520Q were preferentially selected in vitro under cyclopropavir and conferred 12- to 20-fold increases in 50% effective...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21041510
DOI: 10.1128/AAC.01259-10
PMCID: PMC3019618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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