Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing.

doi:10.1128/AAC.45.10.2775-2780.2001

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Article

Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing.

Antimicrobial agents and chemotherapy - 1 Oct 2001

Lurain N S, Weinberg A, Crumpacker C S, Chou S

Abstract excerpt

The widespread use of ganciclovir (GCV) to treat cytomegalovirus (CMV) infections in immunosuppressed patients has led to the development of drug resistance. Phenotypic assays for CMV drug resistance are presently too time-consuming to be therapeutically useful. To support the development of genotypic assays for GCV resistance, the complete sequences of the UL97 phosphotransferase genes in 28 phenotypically...

Topics

Amino Acid Sequence
Amino Acid Substitution
Antiviral Agents
Cytomegalovirus
DNA, Viral
Drug Resistance, Microbial
Genotype
Humans
Microbial Sensitivity Tests
Molecular Sequence Data
Mutation
Phosphotransferases (Alcohol Group Acceptor)
Phylogeny

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Identifiers

PMID: 11557468
DOI: 10.1128/AAC.45.10.2775-2780.2001
PMCID: PMC90730

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