Article
Stability of debrisoquine (CYP2D6) phenotype in liver transplant patients.
Therapeutic drug monitoring - 1 Apr 1995
Bendriss A, Bechtel Y, Paintaud G, Bendriss E K, Joanne C, Bresson-Hadni S, Magnette J, Becker M C, Gillet M, Mantion G
Abstract excerpt
Liver metabolism may be modified after liver transplantation according to the phenotype of the donor and may be influenced by posttransplantation complications. The CYP2D6 phenotype was assessed in 13 patients (group I) before and after liver transplantation using debrisoquine. CYP2D6 activity was also assessed in vitro on microsomes from the liver of the recipients and the donors, using dextromethorphan. Twelve...
Topics
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Dextromethorphan
- Female
- Humans
- Kinetics
- Liver Transplantation
- Male
- Middle Aged
- Mixed Function Oxygenases