Article
Cytochrome P-450IID6 phenotyping in cancer patients: debrisoquin and dextromethorphan as probes.
Cancer chemotherapy and pharmacology - 1 Jan 1995
Anthony L B, Boeve T J, Hande K R
Abstract excerpt
The usefulness of substituting dextromethorphan for debrisoquin as a probe for cytochrome P-450IID6 deficiency was investigated in 20 male cancer patients. Each patient was studied on two occasions. An oral dose of dextromethorphan (60 mg) was administered to 13 patients and are week later an ora...
Topics
- Aged
- Chromatography, Gas
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Dextromethorphan
- Humans
- Male
- Middle Aged
- Mixed Function Oxygenases
- Neoplasm Metastasis
- Neoplasms
- Phenotype
- Regression Analysis
- Sensitivity and Specificity