Disposition of debrisoquine in Caucasians with different CYP2D6-genotypes including those with multiple genes.

doi:10.1097/01213011-199912000-00004

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Article

Disposition of debrisoquine in Caucasians with different CYP2D6-genotypes including those with multiple genes.

Pharmacogenetics - 1 Dec 1999

Dalén P, Dahl M L, Eichelbaum M, Bertilsson L, Wilkinson G R

Abstract excerpt

Debrisoquine is a major prototypic in-vivo probe used to assess polymorphic CYP2D6 activity in humans, based on the 0-8 h urinary excretion of unchanged drug and its 4-hydroxy metabolite (the so-called metabolic ratio). The primary purpose of the study was to investigate further the relationship between genotype and phenotype by determining the overall disposition characteristics of the drug in selected groups of...

Topics

Adolescent
Adult
Area Under Curve
Cytochrome P-450 CYP2D6
Debrisoquin
Female
Genotype
Humans
Male
White People

Source

Open in PubMed

Identifiers

PMID: 10634132
DOI: 10.1097/01213011-199912000-00004

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