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Article

Is debrisoquine hydroxylation modified during acute viral hepatitis?

Fundamental & clinical pharmacology - 1 Jan 1994

Joanne C, Paintaud G, Bresson-Hadni S, Magnette J, Becker M C, Miguet J P, Bechtel P R

Abstract excerpt

Drug metabolism in the liver may be decreased during liver diseases. However, the extent of impairment of specific isozymes of cytochrome P450 is largely unknown. We have studied the debrisoquine hydroxylation capacity of 17 patients with acute viral hepatitis and 106 unrelated healthy subjects. Debrisoquine metabolic ratio was increased in extensive metabolizers (EM) with acute viral hepatitis as compared with...

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Identifiers

PMID: 8181799
DOI: 10.1111/j.1472-8206.1994.tb00782.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Is debrisoquine hydroxylation modified during acute viral hepatitis?PMID 8181799Read ↗

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