Article
Is debrisoquine hydroxylation modified during acute viral hepatitis?
Fundamental & clinical pharmacology - 1 Jan 1994
Joanne C, Paintaud G, Bresson-Hadni S, Magnette J, Becker M C, Miguet J P, Bechtel P R
Abstract excerpt
Drug metabolism in the liver may be decreased during liver diseases. However, the extent of impairment of specific isozymes of cytochrome P450 is largely unknown. We have studied the debrisoquine hydroxylation capacity of 17 patients with acute viral hepatitis and 106 unrelated healthy subjects....
Topics
- Acute Disease
- Adolescent
- Adult
- Aged
- Confidence Intervals
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Female
- Hepatitis, Viral, Human
- Humans
- Hydroxylation
- Male
- Middle Aged
- Mixed Function Oxygenases
- Phenotype