Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation.

Clinical pharmacology and therapeutics - 1 May 2003

Carcillo Joseph A, Adedoyin Adedayo, Burckart Gilbert J, Frye Reginald F, Venkataramanan Raman, Knoll Carmela, Thummel Kenneth, Roskos Lorin, Wilson John W, Sereika Susan, Romkes Marjorie, Bebia Zourab, Branch Robert A

Abstract excerpt

Cytochrome p450 (CYP) 2D6 activity exhibits wide intersubject variation even among individuals with similar genotypes in whom the active enzyme is expressed. There is, therefore, a need to understand the mechanisms involved in determining its activity. The relationship of messenger ribonucleic acid (mRNA) expression to CYP2D6 activity has been evaluated in hepatic and extrahepatic tissues to test the hypothesis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenergic beta-Antagonists
Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Debrisoquin

Share to Ethanolamines

Share to Hydroxylation

Share to Liver Transplantation

Share to Microsomes, Liver

Share to Monocytes

Source

Identifiers

PMID: 12732845
DOI: 10.1016/s0009-9236(03)00055-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation.PMID 12732845Read ↗

CYP2D6 mRNA expression in circulating peripheral blood mononuclear cells correlates with in vivo debrisoquine hydroxylase activity in extensive metabolizers.Semantic proximity Read ↗

Correlation of polymorphic expression of CYP2D6 mRNA in bladder mucosa and tumor tissue to in vivo debrisoquine hydroxylase activity.Semantic proximity Read ↗

Disposition of debrisoquine in Caucasians with different CYP2D6-genotypes including those with multiple genes.Semantic proximity Read ↗

Human liver cytochrome P450 2D6 genotype, full-length messenger ribonucleic acid, and activity assessed with a novel cytochrome P450 2D6 substrate.Semantic proximity Read ↗

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6.Semantic proximity Read ↗

Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship.Semantic proximity Read ↗

Estimation of the interindividual variability of cytochrome 2D6 activity from urinary metabolic ratios in the literature.Semantic proximity Read ↗

Metabolic ratios of four probes of CYP2D6 in Turkish subjects: a cross-over study.Semantic proximity Read ↗

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.Semantic proximity Read ↗

Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity.Semantic proximity Read ↗

Is debrisoquine hydroxylation modified during acute viral hepatitis?Semantic proximity Read ↗

CYP2D6 -1584C>G promoter polymorphism and debrisoquine ultrarapid hydroxylation in healthy volunteers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.