Article
Influence of donor and recipient genotypes on CYP2D6 phenotype after liver transplantation: a study of mutations CYP2D6*3 and CYP2D6*4.
European journal of clinical pharmacology - 1 Mar 1998
Monek O, Paintaud G, Bechtel Y, Miguet J P, Mantion G, Bechtel P R
Abstract excerpt
OBJECTIVE: After liver transplantation (LT), genotypic differences between the recipient and the transplanted liver, medications and post-LT complications may all affect drug metabolism. We have studied the effect of two CYP2D6 mutations in the donor and the recipient on post-LT CYP2D6 phenotype. METHOD: The CYP2D6 phenotype was assessed in 48 patients before and after LT with debrisoquine or dextromethorphan....
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