Influence of donor and recipient genotypes on CYP2D6 phenotype after liver transplantation: a study of mutations CYP2D6*3 and CYP2D6*4.

doi:10.1007/s002280050419

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Article

Influence of donor and recipient genotypes on CYP2D6 phenotype after liver transplantation: a study of mutations CYP2D63 and CYP2D64.

European journal of clinical pharmacology - 1 Mar 1998

Monek O, Paintaud G, Bechtel Y, Miguet J P, Mantion G, Bechtel P R

Abstract excerpt

OBJECTIVE: After liver transplantation (LT), genotypic differences between the recipient and the transplanted liver, medications and post-LT complications may all affect drug metabolism. We have studied the effect of two CYP2D6 mutations in the donor and the recipient on post-LT CYP2D6 phenotype....

Topics

Adult
Aged
Cytochrome P-450 CYP2D6
Debrisoquin
Dextromethorphan
Female
Genotype
Humans
Liver Transplantation
Male
Middle Aged
Mutation
Phenotype
Retrospective Studies

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