Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection.

doi:10.1111/j.1365-2893.2011.01578.x

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Article

Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection.

Journal of viral hepatitis - 1 Aug 2012

Girardin F, Daali Y, Gex-Fabry M, Rebsamen M, Roux-Lombard P, Cerny A, Bihl F, Binek J, Moradpour D, Negro F, Desmeules J

Abstract excerpt

Liver kidney microsomal type 1 (LKM-1) antibodies have been shown to decrease the CYP2D6 activity in vitro and are present in a minority of patients with chronic hepatitis C infection. We investigated whether LKM-1 antibodies might reduce the CYP2D6 activity in vivo. All patients enrolled in the Swiss Hepatitis C Cohort Study and tested for LKM-1 antibodies were assessed (n = 1723): 10 eligible patients were...

Topics

Adult
Aged
Autoantibodies
Cohort Studies
Cytochrome P-450 CYP2D6
Dextromethorphan
Dextrorphan
Female
Genotype
Hepatitis C, Chronic
Humans
Male
Middle Aged
Switzerland

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Open in PubMed

Identifiers

PMID: 22762141
DOI: 10.1111/j.1365-2893.2011.01578.x

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