Article
Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine.
Clinical pharmacology and therapeutics - 1 May 1998
Brynne N, Dalén P, Alván G, Bertilsson L, Gabrielsson J
Abstract excerpt
OBJECTIVE: To determine whether cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of tolterodine by investigating potential differences in pharmacokinetics and pharmacodynamic (heart rate, accommodation, and salivation) of tolterodine and its 5-hydroxymethyl metabolite between poor metab...
Topics
- Administration, Oral
- Adult
- Area Under Curve
- Benzhydryl Compounds
- Cresols
- Cytochrome P-450 CYP2D6
- Debrisoquin
- Half-Life
- Heart Rate
- Humans
- Infusions, Intravenous
- Male
- Metabolic Clearance Rate
- Muscarinic Antagonists
- Phenotype
- Phenylpropanolamine
- Polymorphism, Genetic
- Salivation