Article
Rapid ras-oncogene-mediated transformation maintains steroidogenic differentiation in adrenocortical parenchymal cells.
Differentiation; research in biological diversity - 1 Sept 1995
Roskelley C D, Auersperg N
Abstract excerpt
While its action as a transforming agent is well known, expression of the ras oncogene may also alter tissue-specific differentiation. We have been examining the relationship of transformation and differentiation in steroidogenic cells of the rat. Infection of adrenocortical zona glomerulosa (GLOM) cells with the v-Ki ras containing Kirsten murine sarcoma virus did not induce focus formation. Instead, diffuse...
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