Article
Ras-mutant cancer cells display B-Raf binding to Ras that activates extracellular signal-regulated kinase and is inhibited by protein kinase A phosphorylation.
The Journal of biological chemistry - 20 Sept 2013
Li Yanping, Takahashi Maho, Stork Philip J S
Abstract excerpt
The small G protein Ras regulates proliferation through activation of the mitogen-activated protein (MAP) kinase (ERK) cascade. The first step of Ras-dependent activation of ERK signaling is Ras binding to members of the Raf family of MAP kinase kinase kinases, C-Raf and B-Raf. Recently, it has b...
Topics
- Cell Line, Tumor
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Enzyme Activation
- Extracellular Signal-Regulated MAP Kinases
- Humans
- Lung Neoplasms
- Mutation
- Oncogene Protein p21(ras)
- Phosphorylation
- Protein Binding
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins c-raf
- Signal Transduction