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Article

Inactivation of tumor suppressor genes and deregulation of the c-myc gene in urothelial cancer cell lines.

Urological research - 1 Jan 1995

Grimm M O, Jürgens B, Schulz W A, Decken K, Makri D, Schmitz-Dräger B J

Abstract excerpt

Recent investigations have demonstrated p53 and Rb alterations in a subset of transitional cell carcinoma (TCC). Further genetic changes during tumor progression include overexpression of the c-myc gene in a significant number of mainly invasive bladder tumors. To study the possible interactions between these genes in TCC, urothelial cancer cell lines were chosen as an in vitro model. Expression and mutation of...

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PMID: 8839385
DOI: 10.1007/BF00300017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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