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Article

MDM2 overexpression with alteration of the p53 protein and gene status in oral carcinogenesis.

Japanese journal of cancer research : Gann - 1 May 2000

Li X J, Murai M, Koyama T, Wang D Y, Hashimoto K

Abstract excerpt

In this study, to better understand the mechanism of oral squamous cell carcinoma (SCC) carcinogenesis, alterations of the p53 gene and overexpression of MDM2 and p53 were analyzed in 38 oral SCC samples. Twelve of the 38 specimens revealed mutant-type p53. Moreover, coexpression of MDM2 and p53 was found most frequently in dysplastic lesions (P < 0.05). Expression of MDM2 and p53 was significantly increased in...

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Source

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Identifiers

PMID: 10835493
DOI: 10.1111/j.1349-7006.2000.tb00972.x
PMCID: PMC5926374

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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