Article
hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.
Cancer research - 1 Sept 1994
Liu B, Parsons R E, Hamilton S R, Petersen G M, Lynch H T, Watson P, Markowitz S, Willson J K, Green J, de la Chapelle A
Abstract excerpt
It has recently been shown that hereditary nonpolyposis colorectal cancer (HNPCC) is caused by hereditable defects in DNA mismatch repair genes. However, the fraction of HNPCC due to defects in any one repair gene and the nature of these mutations are not known. We analyzed 29 HNPCC kindreds for mutations in the prototype DNA mismatch repair gene hMSH2 by a combination of linkage analysis, polymerase chain...
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