Article
hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.
Cancer research - 1 Sept 1994
Liu B, Parsons R E, Hamilton S R, Petersen G M, Lynch H T, Watson P, Markowitz S, Willson J K, Green J, de la Chapelle A
Abstract excerpt
It has recently been shown that hereditary nonpolyposis colorectal cancer (HNPCC) is caused by hereditable defects in DNA mismatch repair genes. However, the fraction of HNPCC due to defects in any one repair gene and the nature of these mutations are not known. We analyzed 29 HNPCC kindreds for...
Topics
- Amino Acid Sequence
- Base Sequence
- Codon
- Cohort Studies
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair
- Exons
- Family
- Genetic Linkage
- Humans
- Molecular Sequence Data
- Mutation