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Article

The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population.

BMC medical genetics - 11 Jun 2008

Christensen Lise Lotte, Madsen Bo E, Wikman Friedrik P, Wiuf Carsten, Koed Karen, Tjønneland Anne, Olsen Anja, Syvänen Ann-Christine, Andersen Claus L, Orntoft Torben F

Abstract excerpt

BACKGROUND: Mutations in the mismatch repair genes hMLH1 and hMSH2 predispose to hereditary non-polyposis colorectal cancer (HNPCC). Genetic screening of more than 350 Danish patients with colorectal cancer (CRC) has led to the identification of several new genetic variants (e.g. missense, silent and non-coding) in hMLH1 and hMSH2. The aim of the present study was to investigate the frequency of these variants in...

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PMID: 18547406
DOI: 10.1186/1471-2350-9-52
PMCID: PMC2438340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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