Genomic DNA-based hMSH2 and hMLH1 mutation screening in 32 Eastern United States hereditary nonpolyposis colorectal cancer pedigrees.

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Article

Genomic DNA-based hMSH2 and hMLH1 mutation screening in 32 Eastern United States hereditary nonpolyposis colorectal cancer pedigrees.

Cancer research - 1 Sept 1997

Weber T K, Conlon W, Petrelli N J, Rodriguez-Bigas M, Keitz B, Pazik J, Farrell C, O'Malley L, Oshalim M, Abdo M, Anderson G, Stoler D, Yandell D

Abstract excerpt

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer syndrome characterized by early age of onset colorectal cancer (mean 45 years) as well as endometrial, urinary tract, and upper gastrointestinal adenocarcinomas. The HNPCC phenotype has been shown to segregate with...

Topics

Adult
Base Sequence
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA-Binding Proteins
Family
Female
Genetic Testing
Genotype
Germ-Line Mutation
Humans
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

MutS Homolog 2 Protein

Phenotype

Polymerase Chain Reaction

Proteins

Proto-Oncogene Proteins

United States

Source

Open in PubMed

Identifiers

PMID: 9288790

Genes

MLH1
MSH2
PMS1
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9288790-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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