Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population.

doi:10.1097/00008571-199610000-00008

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Article

Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population.

Pharmacogenetics - 1 Oct 1996

Roh H K, Dahl M L, Johansson I, Ingelman-Sundberg M, Cha Y N, Bertilsson L

Abstract excerpt

One hundred and fifty-two healthy Korean volunteers were phenotyped with debrisoquine and mephenytoin and genotyped with respect to CYP2D6. The debrisoquine metabolic ratio (MR) varied between 0.09 and 6.3, and all subjects were thus classified as extensive metabolizers of debrisoquine. Polymeras...

Topics

Adult
Asian People
Cytochrome P-450 CYP2D6
Debrisoquin
Female
Gene Frequency
Genotype
Humans
Korea
Male
Mephenytoin
Phenotype
Point Mutation
Polymorphism, Genetic

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