CYP2D6 -1584C>G promoter polymorphism and debrisoquine ultrarapid hydroxylation in healthy volunteers.

doi:10.2217/pgs.13.181

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Article

CYP2D6 -1584C>G promoter polymorphism and debrisoquine ultrarapid hydroxylation in healthy volunteers.

Pharmacogenomics - 1 Dec 2013

Llerena Adrian, Dorado Pedro, Ramírez Ronald, Calzadilla Luis R, Peñas-Lledó Eva, Álvarez Mayra, Naranjo María E G, González Idilio, Pérez Bárbaro

Abstract excerpt

BACKGROUND & AIM: The CYP2D6 -1584C>G polymorphism (rs1080985) has been identified as a major factor for CYP2D6 expression and function, with the mutant -1584G promoter type being consistently associated with significantly greater expression than -1584C. It may therefore be associated with ultrarapid metabolism. The objective of the present study was to explore the relationship between the CYP2D6 -1584C>G...

Topics

Alleles
Cytochrome P-450 CYP2D6
Debrisoquin
Gene Expression Regulation
Genotype
Healthy Volunteers
Heterozygote
Humans
Hydroxylation
Polymorphism, Genetic
Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 24279852
DOI: 10.2217/pgs.13.181

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