Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 nuclear immunostaining and gene mutations in non-small-cell lung cancer and their effects on patient survival.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 1995

Mitsudomi T, Oyama T, Nishida K, Ogami A, Osaki T, Nakanishi R, Sugio K, Yasumoto K, Sugimachi K

Abstract excerpt

BACKGROUND: p53 gene mutations are known to occur in about half of all non-small-cell lung cancer (NSCLC) cases. Mutations of the p53 gene usually but not always lead to an increased half life of the p53 protein, and result in a nuclear accumulation of protein which can be detected by immunohistochemistry (IHC). Controversy still exists as to whether the presence of an aberration of the p53 gene or protein is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Genes, p53

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Lung Neoplasms

Share to Mutation

Share to Polymerase Chain Reaction

Share to Polymorphism, Single-Stranded Conformational

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 8616120
DOI: 10.1093/annonc/6.suppl_3.s9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 nuclear immunostaining and gene mutations in non-small-cell lung cancer and their effects on patient survival.PMID 8616120Read ↗

Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small-cell lung cancer.Semantic proximity Read ↗

[p53 alterations in human lung cancer and their correlation with clinicopathological features and prognosis].Semantic proximity Read ↗

p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer. A preliminary report of LCSG 871.Semantic proximity Read ↗

Effects of Tp53 Gene Mutations on the Survival of Non-Small Cell Lung Cancer (NSCLC); A Short ReviewSemantic proximity Read ↗

p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer.Semantic proximity Read ↗

p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.Semantic proximity Read ↗

Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma.Semantic proximity Read ↗

p53 immunostaining is correlated with reduced survival and is not correlated with gene mutations in resected pulmonary large cell carcinomas.Semantic proximity Read ↗

Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis.Semantic proximity Read ↗

Association between p53 mutation and clinicopathological features of non-small cell lung cancer.Semantic proximity Read ↗

p53 gene mutation and protein expression in operable non-small cell lung cancer in Poland.Semantic proximity Read ↗

p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.