Article
p53 nuclear immunostaining and gene mutations in non-small-cell lung cancer and their effects on patient survival.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 1995
Mitsudomi T, Oyama T, Nishida K, Ogami A, Osaki T, Nakanishi R, Sugio K, Yasumoto K, Sugimachi K
Abstract excerpt
BACKGROUND: p53 gene mutations are known to occur in about half of all non-small-cell lung cancer (NSCLC) cases. Mutations of the p53 gene usually but not always lead to an increased half life of the p53 protein, and result in a nuclear accumulation of protein which can be detected by immunohisto...
Topics
- Carcinoma, Non-Small-Cell Lung
- Cell Nucleus
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Lung Neoplasms
- Male
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Survival Rate
- Tumor Suppressor Protein p53