Article
Increased frequency of the uncommon allele of a tumour necrosis factor alpha gene polymorphism in rheumatoid arthritis and systemic lupus erythematosus.
Disease markers - 1 Mar 1995
Danis V A, Millington M, Hyland V, Lawford R, Huang Q, Grennan D
Abstract excerpt
The frequency of the uncommon allele (TNF2) of a polymorphism in the promoter region of the tumour necrosis factor alpha (TNF alpha) gene in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) was found to be 3 times that of the normal anglo-saxon population. In SLE patients, this allele was strongly associated with HLA-DR3 expression and was also more frequent in patients who did not...
Topics
- Alleles
- Arthritis, Rheumatoid
- Female
- HLA-DR Antigens
- Humans
- Lupus Erythematosus, Systemic
- Male
- Polymorphism, Genetic
- Tumor Necrosis Factor-alpha