Article
Increased frequency of the uncommon tumor necrosis factor -857T allele in British and Dutch patients with sarcoidosis.
American journal of respiratory and critical care medicine - 15 Apr 2002
Grutters Jan C, Sato Hiroe, Pantelidis Panagiotis, Lagan Anna L, McGrath Deirdre S, Lammers Jan-Willem J, van den Bosch Jules M M, Wells Athol U, du Bois Roland M, Welsh Kenneth I
Abstract excerpt
Interindividual variation in the expression of tumor necrosis factor (TNF)-alpha suggests the existence of functionally distinct TNF alleles, which might play a role in sarcoidosis. We investigated five potentially functional biallelic TNF promoter polymorphisms at nucleotide positions -1,031(T/C), -863(C/A), -857(C/T), -307(G/A), and -237(G/A) in two clinically well-defined groups of white patients (British [UK]...
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