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Article

A genetic association between systemic lupus erythematosus and tumor necrosis factor alpha

1 Jan 1994

Abstract excerpt

We have investigated the significance of tumor necrosis factor alpha (TNF-alpha) polymorphism in relation to systemic lupus erythematosus (SLE) and autoantibody production. Typing of HLA-B, -DR and TNF was performed in 81 Caucasian SLE patients and 168 Caucasian controls. The presence of anti-Ro and anti-La antibodies was also determined in patients. The frequency of the TNF2 allele increased in SLE compared with...

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Identifiers

PMID: 8020556
DOI: 10.1002/eji.1830240130

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