Article
Association of the tumor necrosis factor alpha gene polymorphism with susceptibility and clinical-immunological findings of systemic lupus erythematosus.
Asian Pacific journal of allergy and immunology - 1 Jan 2000
Azizah M R, Kuak S H, Ainol S S, Rahim M N, Normaznah Y, Norella K
Abstract excerpt
The etiology of systemic lupus erythematosus (SLE) is unknown but genetic factors seem to play a role in the disease pathogenesis. The tumor necrosis factor alpha (TNFa) gene, encoded at the TNF locus in the MHC class III region, is now known to be an important candidate gene in SLE, due to the proinflammatory activities of the TNFa. The objectives of this study were to examine the role of the TNFa polymorphism...
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