Article
Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism.
Human immunology - 1 Jun 2004
Parks Christine G, Pandey Janardan P, Dooley Mary Anne, Treadwell Edward L, St Clair E W, Gilkeson Gary S, Feghali-Bostwick Carol A, Feghali-Botswick Carol L, Cooper Glinda S
Abstract excerpt
Tumor necrosis factor (TNF) is involved in the pathogenesis of systemic lupus erythematosus (SLE), but the role of TNF polymorphisms in SLE susceptibility remains unclear. Previous studies in different populations report an inconsistent association of the TNF-alpha -308A allele with SLE, sometimes depending on the presence of HLA-DR3. We examined the association of polymorphisms in TNF-alpha (-308G/A, -238G/A)...
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