Article
Decreased frequency of the tumor necrosis factor alpha -308 allele in Serbian patients with multiple sclerosis.
European neurology - 1 Jan 2003
Drulović Jelena, Popadić Dusan, Mesaros Sarlota, Dujmović Irena, Cvetković Ivana, Miljković Djordje, Stojsavljević Nebojsa, Pravica Vera, Pekmezović Tatjana, Bogdanović Gradimir, Jarebinski Mirjana, Mostarica Stojković Marija
Abstract excerpt
Tumor necrosis factor (TNF) alpha has been considered the prototypic cytopathogenic cytokine in multiple sclerosis (MS), but recently this cytokine has been shown to possess significant anti-inflammatory and neuroprotective effects in demyelinating diseases. It has been reported that the TNFalpha -308 polymorphism influences levels of TNFalpha production, and that the rare allele, TNF2, is associated with high...
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