Article
An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.
The Journal of experimental medicine - 1 Feb 1993
Wilson A G, de Vries N, Pociot F, di Giovine F S, van der Putte L B, Duff G W
Abstract excerpt
The tumor necrosis factor (TNF) alpha gene lies within the class III region of the major histocompatibility complex (MHC), telomeric to the class II and centromeric to the class I region. We have recently described the first polymorphism within the human TNF-alpha locus. This is biallelic and lie...
Topics
- Alleles
- Base Sequence
- Gene Frequency
- HLA Antigens
- HLA-A1 Antigen
- HLA-B8 Antigen
- HLA-DR3 Antigen
- Haplotypes
- Humans
- Major Histocompatibility Complex
- Molecular Sequence Data
- Oligodeoxyribonucleotides