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Article

A promoter polymorphism of tumor necrosis factor α associated with systemic lupus erythematosus in African‐Americans

1 Dec 1997

Abstract excerpt

OBJECTIVE: The polymorphic tumor necrosis factor alpha (TNFalpha) gene encodes a cytokine involved in inflammation, angiogenesis, and apoptosis. One polymorphic variant is associated with increased production of TNFalpha. This study examined the frequency of this polymorphic variant in African-American patients with systemic lupus erythematosus (SLE) compared with controls. METHODS: We determined the gene...

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PMID: 9416858
DOI: 10.1002/art.1780401215

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