Article
Ultraviolet mutagenesis in human lymphocytes: the effect of cellular transformation.
Experimental cell research - 1 Aug 1992
Parris C N, Kraemer K H
Abstract excerpt
We have assessed the role of cellular transformation in ultraviolet (uv)-induced mutagenic events in human cells. To maintain uniformity of genetic background and to eliminate the effect of DNA repair, primary nontransformed lymphocytes (T-cells) and Epstein-Barr virus-transformed lymphocytes (B-cells) from one patient (XP12Be) with the DNA repair-deficient disorder xeroderma pigmentosum (group A) were...
Topics
- Base Sequence
- Cell Line
- Cell Transformation, Viral
- Genetic Vectors
- Herpesvirus 4, Human
- Humans
- Interleukin-2
- Lymphocytes
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Phytohemagglutinins
