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Article

Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant.

Cancer research - 1 Mar 1999

Cleaver J E, Afzal V, Feeney L, McDowell M, Sadinski W, Volpe J P, Busch D B, Coleman D M, Ziffer D W, Yu Y, Nagasawa H, Little J B

Abstract excerpt

The xeroderma pigmentosum (XP) variant (XPV) is a form of XP that has normal excision repair but shows defective DNA replication after UV irradiation. In developing various transformed fibroblast cell lines from these patients, we have found that there are significant phenotypic changes in transformed cells that seem to correlate with inactivation of p53. After transformation with SV40, XPV cell lines are only...

Topics

Caffeine
Cell Division
Cell Line
Cell Line, Transformed
Cell Survival
Cell Transformation, Viral
DNA Repair
DNA Replication
Dose-Response Relationship, Radiation
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Reporter

Genes, p53

Genetic Variation

Humans

Kinetics

Papillomaviridae

Recombinant Proteins

Simian virus 40

Source

Identifiers

PMID: 10070969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant.PMID 10070969Read ↗

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