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Article

Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant.

Cancer research - 1 Mar 1999

Cleaver J E, Afzal V, Feeney L, McDowell M, Sadinski W, Volpe J P, Busch D B, Coleman D M, Ziffer D W, Yu Y, Nagasawa H, Little J B

Abstract excerpt

The xeroderma pigmentosum (XP) variant (XPV) is a form of XP that has normal excision repair but shows defective DNA replication after UV irradiation. In developing various transformed fibroblast cell lines from these patients, we have found that there are significant phenotypic changes in transformed cells that seem to correlate with inactivation of p53. After transformation with SV40, XPV cell lines are only...

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PMID: 10070969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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