Article
Mutation and expression of the XPA gene in revertants and hybrids of a xeroderma pigmentosum cell line.
Somatic cell and molecular genetics - 1 Jul 1994
Cleaver J E, McDowell M, Jones C, Wood R, Karentz D
Abstract excerpt
A series of ultraviolet (UV)-resistant cell lines have been generated from a UV-sensitive XP group A cell line homozygous for a stop codon (TGA) in the chromosome 9 XPA gene. Three lines generated by chemical mutagenesis acquired the ability to excise (6-4) photoproducts but not cyclobutane dimer...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cell Line, Transformed
- Cricetinae
- Cricetulus
- DNA Repair
- DNA-Binding Proteins
- Humans
- Hybrid Cells
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Pyrimidine Dimers
- Xeroderma Pigmentosum
- Xeroderma Pigmentosum Group A Protein