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Article

Suppression of malignant phenotype in a human prostate cancer cell line by fragments of normal chromosomal region 17q.

Cancer research - 1 Aug 1995

Murakami Y S, Brothman A R, Leach R J, White R L

Abstract excerpt

Recent evidence obtained by in situ hybridization indicates that chromosomal region 17q is often lost in prostate tumors. To substantiate the presence of tumor suppressor genes in this chromosomal region, normal human 17q tagged with a neomycin resistance gene was transferred into a human prostate cancer cell line, PPC-1, by microcell-mediated chromosome transfer. Two hybrid clones were obtained, both of which...

Topics

Animals
Chromosome Mapping
Chromosomes, Human, Pair 17
Gene Transfer Techniques
Genes, Tumor Suppressor
Genetic Markers
Humans
Male
Mice
Mice, Inbred BALB C
Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Transplantation

Phenotype

Prostatic Neoplasms

Tumor Cells, Cultured

Tumor Stem Cell Assay

Source

Identifiers

PMID: 7614477

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7614477-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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