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Article

Stepwise genetic changes associated with progression of nontumorigenic HPV-18 immortalized human prostate cancer-derived cell line to a malignant phenotype.

Cancer genetics and cytogenetics - 15 Jul 2000

Hukku B, Mally M, Cher M L, Peehl D M, Kung H, Rhim J S

Abstract excerpt

Cytogenetics, fluorescence in situ hybridization (FISH), and comparative genomic hybridization (CGH) were used to identify genes that are involved in the development and progression of prostate cancer. For that purpose, we chose a cell line established in vitro from a prostatic adenocarcinoma which was nontumorigenic in nude mice and followed its progression to a tumorigenic cell line. Stepwise changes were...

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PMID: 10942801
DOI: 10.1016/s0165-4608(00)00216-8

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