Article
Genetic alterations in localized prostate cancer: identification of a common region of deletion on chromosome arm 18q.
Genes, chromosomes & cancer - 1 Oct 1994
Latil A, Baron J C, Cussenot O, Fournier G, Soussi T, Boccon-Gibod L, Le Duc A, Rouëssé J, Lidereau R
Abstract excerpt
Accumulation of mutations in oncogenes and tumor suppressor genes transforms a normal cell into a malignant cell by allowing it to escape from normal control of growth. In prostate tumorigenesis, the current model envisages specific mutations of the TP53 tumor suppressor gene and loss of loci, de...
Topics
- Alleles
- Base Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 18
- Chromosomes, Human, Pair 7
- Chromosomes, Human, Pair 8
- DNA, Neoplasm
- Genes, p53
- Humans
- Male
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational