Suppression of tumorigenicity of human prostate cancer cells by introduction of human chromosome del(12)(q13).

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Article

Suppression of tumorigenicity of human prostate cancer cells by introduction of human chromosome del(12)(q13).

Cancer research - 15 Jun 1994

Bérubé N G, Speevak M D, Chevrette M

Abstract excerpt

The introduction of normal chromosomes into tumor cells by microcell fusion-mediated transfer is a powerful technique to identify putative tumor suppressor genes. We have used this approach to independently transfer human chromosomes 3 and 12 into a human prostate cancer cell line, DU 145. We sho...

Topics

Animals
Cell Fusion
Chromosomes, Human, Pair 12
Gene Transfer Techniques
Genes, Tumor Suppressor
Genetic Therapy
Genetic Vectors
Humans
Hybrid Cells
Male
Melanoma, Experimental
Mice
Mice, Nude
Phenotype
Prostatic Neoplasms
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8205520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8205520-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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