Molecular genetic changes in human male germ cell tumors.

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Article

Molecular genetic changes in human male germ cell tumors.

Laboratory investigation; a journal of technical methods and pathology - 1 Nov 1995

Lothe R A, Peltomäki P, Tommerup N, Fosså S D, Stenwig A E, Børresen A L, Nesland J M

Abstract excerpt

BACKGROUND: An isochromosome for the short arm of chromosome 12, i(12p), is the most common and characteristic cytogenetic aberration in testicular germ cell tumors. Little is known about the molecular genetic abnormalities of these neoplasms. EXPERIMENTAL DESIGN: A total of 32 loci were studied...

Topics

Alleles
Antigens, Neoplasm
Blotting, Southern
Chromosomes, Human, Pair 3
DNA
Genes, Tumor Suppressor
Genes, p53
Heterozygote
Humans
Ki-67 Antigen
Male
Neoplasm Proteins
Neoplasms, Germ Cell and Embryonal
Nuclear Proteins
Seminoma
Testicular Neoplasms

Source

Open in PubMed

Identifiers

PMID: 7474934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7474934-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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