Article

Role of P53 and MDM2 in Treatment Response of Human Germ Cell Tumors

2002-03-15

Abstract excerpt

PURPOSE: Testicular germ cell tumors (TGCTs) of adolescents and adults are very sensitive to systemic treatment. The exquisite chemosensitivity of these cancers has been attributed to a high level of wild-type P53. MATERIALS AND METHODS: To clarify the role of P53 in treatment sensitivity and resistance of TGCTs, we performed immunohistochemistry and Western blotting analysis on a series of 39 fresh-frozen primary...

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Literature Corpus work: cb8c3f17-0d9f-5915-aba5-a11e6e9f6776
DOI: 10.1200/jco.20.6.1551

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