Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of P53 and MDM2 in Treatment Response of Human Germ Cell Tumors

15 Mar 2002

Abstract excerpt

PURPOSE: Testicular germ cell tumors (TGCTs) of adolescents and adults are very sensitive to systemic treatment. The exquisite chemosensitivity of these cancers has been attributed to a high level of wild-type P53. MATERIALS AND METHODS: To clarify the role of P53 in treatment sensitivity and resistance of TGCTs, we performed immunohistochemistry and Western blotting analysis on a series of 39 fresh-frozen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Sperm and Testicular Function
Share to Testicular diseases and treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11896104
DOI: 10.1200/jco.2002.20.6.1551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of P53 and MDM2 in Treatment Response of Human Germ Cell TumorsPMID 11896104Read ↗

Role of P53 and MDM2 in Treatment Response of Human Germ Cell TumorsSemantic proximity Read ↗

Therapeutic potential of Mdm2 inhibition in malignant germ cell tumours.Semantic proximity Read ↗

Human male germ cell tumor resistance to cisplatin is linked to TP53 gene mutation.Semantic proximity Read ↗

Is p53 expression, detected by immunohistochemistry, an important parameter of response to treatment in testis cancer?Semantic proximity Read ↗

Revisiting DNA damage repair, p53-mediated apoptosis and cisplatin sensitivity in germ cell tumorsSemantic proximity Read ↗

p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumorsSemantic proximity Read ↗

Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors.Semantic proximity Read ↗

Testicular germ cell tumor genomics.Semantic proximity Read ↗

The chemosensitivity of testicular germ cell tumorsSemantic proximity Read ↗

The p53 and mdm-2 genes in human testicular germ-cell tumors.Semantic proximity Read ↗

The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors.Semantic proximity Read ↗

Cisplatin resistance in germ cell tumours: models and mechanismsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.