Article
Immunohistochemical and mutational analysis of the p53 tumour suppressor gene and the bcl-2 oncogene in primary testicular germ cell tumours.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jan 1998
Heidenreich A, Schenkman N S, Sesterhenn I A, Mostofi K F, Moul J W, Srivastava S, Engelmann U H
Abstract excerpt
The role of p53 in testicular germ cell tumours is still contradictory based on the finding of immunohistochemical overexpression at the protein level, but lack of mutations at the DNA level. In addition, p53 wild-type activity has been demonstrated in cell culture experiments. Overexpression of...
Topics
- Animals
- DNA Mutational Analysis
- Genes, Tumor Suppressor
- Genes, bcl-2
- Germinoma
- Humans
- Immunohistochemistry
- Male
- Mutation
- Proto-Oncogene Mas
- Proto-Oncogene Proteins c-bcl-2
- Rabbits
- Testicular Neoplasms
- Tumor Suppressor Protein p53