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Article

Immunohistochemical and mutational analysis of the p53 tumour suppressor gene and the bcl-2 oncogene in primary testicular germ cell tumours.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jan 1998

Heidenreich A, Schenkman N S, Sesterhenn I A, Mostofi K F, Moul J W, Srivastava S, Engelmann U H

Abstract excerpt

The role of p53 in testicular germ cell tumours is still contradictory based on the finding of immunohistochemical overexpression at the protein level, but lack of mutations at the DNA level. In addition, p53 wild-type activity has been demonstrated in cell culture experiments. Overexpression of the proto-oncogene bcl-2 might block p53-induced apoptosis and might inhibit p53 functional activity. To clarify the...

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Identifiers

PMID: 9524567
DOI: 10.1111/j.1699-0463.1998.tb01324.x

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