Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Construction of intertypic chimeric dengue viruses exhibiting type 3 antigenicity and neurovirulence for mice

1 Aug 1995

Abstract excerpt

There are four dengue virus serotypes (DEN1 to -4), each of which causes major epidemics in tropical or subtropical areas. The current strategy for dengue virus immunization favors the use of a tetravalent vaccine preparation. We have previously employed full-length DEN4 cDNA to construct a viable intertypic dengue virus type 1 or type 2 chimera that contained the C-PreM-E or only the PreM-E genes of DEN1 or DEN2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mosquito-borne diseases and control
Share to Viral Infections and Outbreaks Research
Share to Virology and Viral Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7609092
DOI: 10.1128/jvi.69.8.5186-5190.1995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Construction of intertypic chimeric dengue viruses exhibiting type 3 antigenicity and neurovirulence for micePMID 7609092Read ↗

Construction of intertypic chimeric dengue viruses by substitution of structural protein genes.Semantic proximity Read ↗

Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys.Semantic proximity Read ↗

Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in miceSemantic proximity Read ↗

West Nile virus/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacySemantic proximity Read ↗

Japanese encephalitis virus vaccine candidates generated by chimerization with dengue virus type 4.Semantic proximity Read ↗

Genetic determinants of dengue type 4 virus neurovirulence for miceSemantic proximity Read ↗

Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Δ30 with those of DEN1Semantic proximity Read ↗

Systematic mutational analysis of epitope-grafted ED3’s immunogenicity reveals a DENV3-DENV4 bi-serospecific ED3 mutantSemantic proximity Read ↗

Genetic determinants responsible for acquisition of dengue type 2 virus mouse neurovirulence.Semantic proximity Read ↗

Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization.Semantic proximity Read ↗

Chimeric rhinoviruses as tools for vaccine development and characterization of protein epitopes.Semantic proximity Read ↗

Development of a Live Attenuated Dengue Virus Vaccine Using Reverse GeneticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.