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Article

Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization.

PLoS neglected tropical diseases - 1 Jan 2012

Messer William B, Yount Boyd, Hacker Kari E, Donaldson Eric F, Huynh Jeremy P, de Silva Aravinda M, Baric Ralph S

Abstract excerpt

Dengue viruses (DENV) are enveloped single-stranded positive-sense RNA viruses transmitted by Aedes spp. mosquitoes. There are four genetically distinct serotypes designated DENV-1 through DENV-4, each further subdivided into distinct genotypes. The dengue scientific community has long contended that infection with one serotype confers lifelong protection against subsequent infection with the same serotype,...

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Identifiers

PMID: 22389731
DOI: 10.1371/journal.pntd.0001486
PMCID: PMC3289595

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