Article
Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys.
Vaccine - 1 Oct 2003
Whitehead Stephen S, Hanley Kathryn A, Blaney Joseph E, Gilmore Lara E, Elkins William R, Murphy Brian R
Abstract excerpt
Antigenic chimeric viruses in which the structural genes of dengue virus type 4 (DEN4) have been replaced with those derived from dengue virus type 2 (DEN2) have been created and evaluated as a first step in generating a live attenuated tetravalent dengue virus vaccine. Specifically, the capsid, membrane precursor, and envelope (CME) or the membrane precursor and envelope (ME) gene regions of DEN2 were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.