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Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice

1 Aug 1993

Abstract excerpt

Two new chimeric flaviviruses were constructed from full-length cDNAs that contained tick-borne encephalitis virus (TBEV) CME or ME structural protein genes and the remaining genes derived from dengue type 4 virus (DEN4). Studies involving mice inoculated intracerebrally with the ME chimeric virus indicated that it retained the neurovirulence of its TBEV parent from which its pre-M and E genes were derived....

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PMID: 8331735
DOI: 10.1128/jvi.67.8.4956-4963.1993

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