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Construction of intertypic chimeric dengue viruses by substitution of structural protein genes.

15 Nov 1991

Abstract excerpt

Dengue virus contains an 11-kilobase positive-strand RNA genome that codes for, in one open reading frame, three structural proteins (capsid, premembrane, and envelope), followed by seven nonstructural proteins. The structural protein genes of a full-length cDNA clone of type 4 dengue virus were replaced with the corresponding genes of dengue 1 or dengue 2 to create intertypic chimeric cDNA. The RNA transcripts...

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Identifiers

PMID: 1682924
DOI: 10.1073/pnas.88.22.10342

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