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Article

Genetic determinants of dengue type 4 virus neurovirulence for mice

1 Nov 1993

Abstract excerpt

Mouse-adapted dengue type 4 virus (DEN4) strain H241 is highly neurovirulent for mice, whereas its non-mouse-adapted parent is rarely neurovirulent. The genetic basis for the neurovirulence of the mouse-adapted mutant was studied by comparing intratypic chimeric viruses that contained the three structural protein genes from the parental virus or the neurovirulent mutant in the background sequence of...

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Identifiers

PMID: 8411360
DOI: 10.1128/jvi.67.11.6567-6575.1993

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