Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

West Nile virus/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacy

5 Mar 2002

Abstract excerpt

A candidate live attenuated vaccine strain was constructed for West Nile virus (WN), a neurotropic flavivirus that has recently emerged in the U.S. Considerable attenuation for mice was achieved by chimerization with dengue virus type 4 (DEN4). The genes for the structural premembrane and envelope proteins of DEN4 present in an infectious cDNA clone were replaced by the corresponding genes of WN strain NY99. Two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Malaria Research and Control
Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11880643
DOI: 10.1073/pnas.022652799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

West Nile virus/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacyPMID 11880643Read ↗

Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys.Semantic proximity Read ↗

ChimeriVax-West Nile Virus Live-Attenuated Vaccine: Preclinical Evaluation of Safety, Immunogenicity, and EfficacySemantic proximity Read ↗

Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Δ30 with those of DEN1Semantic proximity Read ↗

Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in miceSemantic proximity Read ↗

Chimeric dengue 2 PDK-53/West Nile NY99 viruses retain the phenotypic attenuation markers of the candidate PDK-53 vaccine virus and protect mice against lethal challenge with West Nile virus.Semantic proximity Read ↗

Systematic analysis of viral genes responsible for differential virulence between American and Australian West Nile virus strainsSemantic proximity Read ↗

Development of a Live Attenuated Dengue Virus Vaccine Using Reverse GeneticsSemantic proximity Read ↗

Construction of intertypic chimeric dengue viruses by substitution of structural protein genes.Semantic proximity Read ↗

Protective Efficacy of a Chimeric Insect-Specific Flavivirus Vaccine against West Nile VirusSemantic proximity Read ↗

A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence.Semantic proximity Read ↗

Construction of intertypic chimeric dengue viruses exhibiting type 3 antigenicity and neurovirulence for miceSemantic proximity Read ↗

Molecular Basis for Attenuation of Neurovirulence of a Yellow Fever Virus/Japanese Encephalitis Virus Chimera Vaccine (ChimeriVax-JE)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.