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Systematic mutational analysis of epitope-grafted ED3’s immunogenicity reveals a DENV3-DENV4 bi-serospecific ED3 mutant

2020-04-30

Abstract excerpt

Dengue viruses are classified into four serotypes (DENV1∼4), and the severe forms of dengue disease, the dengue hemorrhagic fever and shock syndrome, are caused by sero-cross-reacting antibodies. However, the residue determinants of the serospecificity and sero-cross-reactivity are yet to be identified. Here, we report an epitope grafting mutational analysis of the serospecificity and cross-serospecificity of the...

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Literature Corpus work
f938b938-86e4-5a7e-b37c-83e4d7246f6b
DOI
10.1101/2020.04.30.070250
Open publication

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Systematic mutational analysis of epitope-grafted ED3’s immunogenicity reveals a DENV3-DENV4 bi-serospecific ED3 mutantDOI 10.1101/2020.04.30.070250
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